Assay Detail

CHEMBL5515078

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Binding

Inhibition of CDK1 (unknown origin)

ChEMBL ↗

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Target

Cyclin-dependent kinase 1 (CHEMBL308) ↗

Open DB target context

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Cyclin-dependent kinase 1 (CHEMBL308) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 1

CHEMBL308

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cyclin-dependent kinase 1 (CHEMBL308) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Drug development and potential targets for Cushing's syndrome.

Wei W, Xu Q, Wu L, Gong G, Tian Y, Huang H, Li Z.
Eur J Med Chem (2024) 270 : 116333 -116333
PubMed 38569434 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.70	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4442620	RONICICLIB	2.0	1	8.05
CHEMBL564829	MILCICLIB	2.0	1	7.35

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4442620	RONICICLIB	IC50	=	9.0	nM	8.05
CHEMBL564829	MILCICLIB	IC50	=	45.0	nM	7.35