Assay Detail
Binding
CHEMBL5515079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug development and potential targets for Cushing's syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.27 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5201870 | TEGTOCICLIB | 2.0 | 1 | 8.96 |
| CHEMBL5095094 | CULMERCICLIB | 2.0 | 1 | 8.62 |
| CHEMBL3655762 | CYC-065 | 2.0 | 1 | 8.35 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.05 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5201870 | TEGTOCICLIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5095094 | CULMERCICLIB | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3655762 | CYC-065 | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 45.0 | nM | 7.35 |