Assay Detail
Binding
CHEMBL5515082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug development and potential targets for Cushing's syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.50 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655762 | CYC-065 | 2.0 | 1 | 8.35 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.05 |
| CHEMBL4594423 | TP-1287 | 1.0 | 1 | 8.00 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 7.37 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 6.82 |
| CHEMBL3905910 | VORUCICLIB | 2.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655762 | CYC-065 | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4594423 | TP-1287 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3905910 | VORUCICLIB | IC50 | = | 400.0 | nM | 6.40 |