Assay Detail
Binding
CHEMBL5515098
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Inhibition of recombinant human FABP1 incubated for 3 mins by fluorescence based analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of first-in-class FABP1 inhibitors for the treatment of NASH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.88 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556772 | — | — | 1 | 5.35 |
| CHEMBL5517962 | — | — | 1 | 5.14 |
| CHEMBL5558673 | — | — | 1 | 5.06 |
| CHEMBL5559644 | — | — | 1 | 5.06 |
| CHEMBL5532188 | — | — | 1 | 4.93 |
| CHEMBL5542459 | — | — | 1 | 4.84 |
| CHEMBL5557198 | — | — | 1 | 4.78 |
| CHEMBL5563466 | — | — | 1 | 4.68 |
| CHEMBL4857372 | — | — | 1 | 4.04 |
| CHEMBL5556473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556772 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL5517962 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL5558673 | — | IC50 | = | 8710.0 | nM | 5.06 |
| CHEMBL5559644 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL5532188 | — | IC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL5542459 | — | IC50 | = | 14550.0 | nM | 4.84 |
| CHEMBL5557198 | — | IC50 | = | 16510.0 | nM | 4.78 |
| CHEMBL5563466 | — | IC50 | = | 21010.0 | nM | 4.68 |
| CHEMBL4857372 | — | IC50 | = | 91340.0 | nM | 4.04 |
| CHEMBL5556473 | — | IC50 | = | 498120.0 | nM | - |