Assay Detail
Binding
CHEMBL5515136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MDM2/p53 (unknown origin) interaction by fluorescence polarization assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.27 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560431 | — | — | 1 | 9.40 |
| CHEMBL5560586 | — | — | 1 | 9.22 |
| CHEMBL5425989 | — | — | 1 | 9.15 |
| CHEMBL5558118 | — | — | 1 | 9.00 |
| CHEMBL5542912 | — | — | 1 | 9.00 |
| CHEMBL5549791 | — | — | 1 | 8.92 |
| CHEMBL5532484 | — | — | 1 | 8.92 |
| CHEMBL5561895 | — | — | 1 | 8.92 |
| CHEMBL5565747 | — | — | 1 | 8.89 |
| CHEMBL2381408 | SAR-405838 | 1.0 | 1 | 8.89 |
| CHEMBL2402734 | — | — | 1 | 8.74 |
| CHEMBL5560521 | — | — | 1 | 8.57 |
| CHEMBL5556588 | — | — | 1 | 8.57 |
| CHEMBL5568457 | — | — | 1 | 8.51 |
| CHEMBL5542517 | — | — | 1 | 8.51 |
| CHEMBL5532632 | — | — | 1 | 8.28 |
| CHEMBL5564909 | — | — | 1 | 8.28 |
| CHEMBL5523604 | — | — | 1 | 8.12 |
| CHEMBL5542298 | — | — | 1 | 8.02 |
| CHEMBL5561291 | — | — | 1 | 7.83 |
| CHEMBL5557103 | — | — | 1 | 7.55 |
| CHEMBL5560797 | — | — | 1 | 7.48 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 7.37 |
| CHEMBL5555581 | — | — | 1 | 7.30 |
| CHEMBL5558411 | — | — | 1 | 7.17 |
| CHEMBL5558286 | — | — | 1 | 6.82 |
| CHEMBL5560663 | — | — | 1 | 5.96 |
| CHEMBL5558590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560431 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL5560586 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL5425989 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL5558118 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5542912 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5549791 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL5532484 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL5561895 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL5565747 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2381408 | SAR-405838 | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2402734 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL5560521 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL5556588 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL5568457 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL5542517 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL5532632 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL5564909 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL5523604 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL5542298 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL5561291 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL5557103 | — | Ki | = | 27.9 | nM | 7.55 |
| CHEMBL5560797 | — | Ki | = | 32.8 | nM | 7.48 |
| CHEMBL191334 | NUTLIN-3 | Ki | = | 42.6 | nM | 7.37 |
| CHEMBL5555581 | — | Ki | = | 50.5 | nM | 7.30 |
| CHEMBL5558411 | — | Ki | = | 67.4 | nM | 7.17 |
| CHEMBL5558286 | — | Ki | = | 151.6 | nM | 6.82 |
| CHEMBL5560663 | — | Ki | = | 1088.0 | nM | 5.96 |
| CHEMBL5558590 | — | Ki | > | 27000.0 | nM | - |