Assay Detail
Functional
CHEMBL5515178
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Antiproliferative activity against human SW480 cells incubated for 4 days by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.15 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558118 | — | — | 1 | 5.31 |
| CHEMBL2402734 | — | — | 1 | 5.26 |
| CHEMBL5560431 | — | — | 1 | 5.23 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558118 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL2402734 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL5560431 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 16380.0 | nM | 4.79 |