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Assay Detail

CHEMBL5515844

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Irreversible inhibition of DNA polymerase beta (unknown origin) assessed as inhibition constant by Kitz-Wilson plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

DNA polymerase beta (CHEMBL2392)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update.
Hillebrand L, Liang XJ, Serafim RAM, Gehringer M.
J Med Chem (2024) 67 : 7668 -7758
PubMed 38711345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.75 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5557939 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5557939 Ki = 1800.0 nM 5.75