Assay Detail
Binding
CHEMBL5516199
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Inhibition of cathepsin B (unknown origin) using Z-Arg-Arg-pNA as substrate incubated for 60 mins
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.07 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561728 | — | — | 1 | 8.23 |
| CHEMBL5562042 | — | — | 1 | 7.60 |
| CHEMBL5564971 | — | — | 1 | 7.40 |
| CHEMBL5558707 | — | — | 1 | 7.28 |
| CHEMBL5559134 | — | — | 1 | 7.15 |
| CHEMBL5566531 | — | — | 1 | 7.14 |
| CHEMBL5549898 | — | — | 1 | 7.01 |
| CHEMBL5568269 | — | — | 1 | 6.97 |
| CHEMBL5557407 | — | — | 1 | 6.72 |
| CHEMBL5560304 | — | — | 1 | 6.66 |
| CHEMBL5565472 | — | — | 1 | 6.63 |
| CHEMBL5558496 | — | — | 1 | 6.61 |
| CHEMBL5559003 | — | — | 1 | 6.57 |
| CHEMBL5564222 | — | — | 1 | - |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | - |
| CHEMBL5559371 | — | — | 1 | - |
| CHEMBL5559068 | — | — | 1 | - |
| CHEMBL5568382 | — | — | 1 | - |
| CHEMBL5560182 | — | — | 1 | - |
| CHEMBL5532074 | — | — | 1 | - |
| CHEMBL5556766 | — | — | 1 | - |
| CHEMBL5562393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561728 | — | Ki | = | 5.93 | nM | 8.23 |
| CHEMBL5562042 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5564971 | — | Ki | = | 40.1 | nM | 7.40 |
| CHEMBL5558707 | — | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL5559134 | — | Ki | = | 71.2 | nM | 7.15 |
| CHEMBL5566531 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL5549898 | — | Ki | = | 98.1 | nM | 7.01 |
| CHEMBL5568269 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL5557407 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL5560304 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL5565472 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL5558496 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL5559003 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL5564222 | — | Ki | - | — | - | |
| CHEMBL4802135 | NIRMATRELVIR | Ki | - | — | - | |
| CHEMBL5559371 | — | Ki | - | — | - | |
| CHEMBL5559068 | — | Ki | - | — | - | |
| CHEMBL5568382 | — | Ki | - | — | - | |
| CHEMBL5560182 | — | Ki | - | — | - | |
| CHEMBL5532074 | — | Ki | - | — | - | |
| CHEMBL5556766 | — | Ki | - | — | - | |
| CHEMBL5562393 | — | Ki | - | — | - |