Assay Detail
Functional
CHEMBL5516208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 JPN/TY/WK-521 infected in VeroE6/TMPRSS2 cells assessed as reduction in viral RNA incubated with virus for 1 hr followed by compound addition and measured after 24 hrs by RT-PCR analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | VeroE6/TMPRSS2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.67 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 6.07 |
| CHEMBL5568269 | — | — | 1 | 5.68 |
| CHEMBL5568382 | — | — | 1 | 5.67 |
| CHEMBL5565472 | — | — | 1 | 5.59 |
| CHEMBL5559068 | — | — | 1 | 5.59 |
| CHEMBL5561728 | — | — | 1 | 5.41 |
| CHEMBL5558707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5568269 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5568382 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5565472 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5559068 | — | EC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL5561728 | — | EC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL5558707 | — | EC50 | - | — | - |