Assay Detail
Binding
CHEMBL5516355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CD45 (620 to 1236 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate incubated for 10 mins by fluorescence based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase C (CHEMBL3243) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.51 | 4.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568311 | — | — | 1 | 4.67 |
| CHEMBL5567968 | — | — | 1 | 4.50 |
| CHEMBL5555119 | — | — | 1 | 4.37 |
| CHEMBL57974 | — | — | 1 | - |
| CHEMBL5563600 | — | — | 1 | - |
| CHEMBL5559251 | — | — | 1 | - |
| CHEMBL5560087 | — | — | 1 | - |
| CHEMBL5556892 | — | — | 1 | - |
| CHEMBL5561438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568311 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL5567968 | — | IC50 | = | 31340.0 | nM | 4.50 |
| CHEMBL5555119 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL57974 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL5563600 | — | IC50 | = | 234800.0 | nM | - |
| CHEMBL5559251 | — | IC50 | = | 107100.0 | nM | - |
| CHEMBL5560087 | — | IC50 | = | 339000.0 | nM | - |
| CHEMBL5556892 | — | IC50 | = | 477650.0 | nM | - |
| CHEMBL5561438 | — | IC50 | > | 500000.0 | nM | - |