Assay Detail
Binding
CHEMBL5516359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHP-1 (245 to 543 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate incubated for 10 mins by fluorescence based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.46 | 4.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567968 | — | — | 1 | 4.81 |
| CHEMBL5555119 | — | — | 1 | 4.64 |
| CHEMBL5559251 | — | — | 1 | 4.44 |
| CHEMBL5563600 | — | — | 1 | 4.24 |
| CHEMBL5568311 | — | — | 1 | 4.19 |
| CHEMBL57974 | — | — | 1 | - |
| CHEMBL5560087 | — | — | 1 | - |
| CHEMBL5556892 | — | — | 1 | - |
| CHEMBL5561438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567968 | — | IC50 | = | 15470.0 | nM | 4.81 |
| CHEMBL5555119 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL5559251 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL5563600 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL5568311 | — | IC50 | = | 64700.0 | nM | 4.19 |
| CHEMBL57974 | — | IC50 | = | 5730000.0 | nM | - |
| CHEMBL5560087 | — | IC50 | = | 138700.0 | nM | - |
| CHEMBL5556892 | — | IC50 | = | 167300.0 | nM | - |
| CHEMBL5561438 | — | IC50 | > | 500000.0 | nM | - |