Assay Detail
Binding
CHEMBL5516360
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Inhibition of human CDC14A using DiFMUP as substrate incubated for 10 mins by fluorescence based assay
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein phosphatase CDC14A (CHEMBL1772926) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.62 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567968 | — | — | 2 | 7.05 |
| CHEMBL5568076 | — | — | 1 | 5.72 |
| CHEMBL5560702 | — | — | 1 | 5.70 |
| CHEMBL5568214 | — | — | 1 | 5.66 |
| CHEMBL5563039 | — | — | 1 | 5.56 |
| CHEMBL5565218 | — | — | 1 | 5.56 |
| CHEMBL5556755 | — | — | 1 | 5.49 |
| CHEMBL5542122 | — | — | 1 | 5.03 |
| CHEMBL5561438 | — | — | 1 | 5.01 |
| CHEMBL5568311 | — | — | 1 | 4.01 |
| CHEMBL57974 | — | — | 1 | - |
| CHEMBL5563600 | — | — | 1 | - |
| CHEMBL5555119 | — | — | 1 | - |
| CHEMBL5559251 | — | — | 1 | - |
| CHEMBL5560087 | — | — | 1 | - |
| CHEMBL5556892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567968 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5567968 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5568076 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5560702 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5568214 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL5565218 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL5563039 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL5556755 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5542122 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL5561438 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL5568311 | — | IC50 | = | 98700.0 | nM | 4.01 |
| CHEMBL57974 | — | IC50 | = | 3269000.0 | nM | - |
| CHEMBL5556892 | — | IC50 | = | 360000.0 | nM | - |
| CHEMBL5560087 | — | IC50 | = | 339000.0 | nM | - |
| CHEMBL5559251 | — | IC50 | = | 273200.0 | nM | - |
| CHEMBL5555119 | — | IC50 | = | 119600.0 | nM | - |
| CHEMBL5563600 | — | IC50 | = | 220600.0 | nM | - |