Assay Detail
Functional
CHEMBL5516416
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Antibacterial activity against Bacillus subtilis assessed as reduction in bacterial cell viability incubated for 24 hrs by nutrient agar plate method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bacillus subtilis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Secondary Structure Stabilization of Macrocyclic Antimicrobial Peptides via Cross-Link Swapping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.80 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174 | AMPICILLIN | 4.0 | 1 | 6.00 |
| CHEMBL5556492 | — | — | 1 | 5.00 |
| CHEMBL5558688 | — | — | 1 | 4.98 |
| CHEMBL5568536 | — | — | 1 | 4.82 |
| CHEMBL5556572 | — | — | 1 | 4.81 |
| CHEMBL5557174 | — | — | 1 | 4.62 |
| CHEMBL5549852 | — | — | 1 | 4.47 |
| CHEMBL5532002 | — | — | 1 | 4.44 |
| CHEMBL5568242 | — | — | 1 | 4.42 |
| CHEMBL5560453 | — | — | 1 | 4.40 |
| CHEMBL5560867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174 | AMPICILLIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5556492 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5558688 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5568536 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5556572 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5557174 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL5549852 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL5532002 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL5568242 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL5560453 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5560867 | — | IC50 | = | 461000.0 | nM | - |