Assay Detail
Functional
CHEMBL5516417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antibacterial activity against Staphylococcus epidermidis assessed as reduction in bacterial cell viability incubated for 24 hrs by nutrient agar plate method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus epidermidis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Secondary Structure Stabilization of Macrocyclic Antimicrobial Peptides via Cross-Link Swapping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.12 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568536 | — | — | 1 | 5.46 |
| CHEMBL5558688 | — | — | 1 | 5.43 |
| CHEMBL5556572 | — | — | 1 | 5.41 |
| CHEMBL5532002 | — | — | 1 | 5.14 |
| CHEMBL5556492 | — | — | 1 | 5.10 |
| CHEMBL5560867 | — | — | 1 | 5.07 |
| CHEMBL174 | AMPICILLIN | 4.0 | 1 | 5.07 |
| CHEMBL5560453 | — | — | 1 | 5.03 |
| CHEMBL5568242 | — | — | 1 | 4.99 |
| CHEMBL5557174 | — | — | 1 | 4.92 |
| CHEMBL5549852 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568536 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5558688 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5556572 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5532002 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5556492 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5560867 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL174 | AMPICILLIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5560453 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5568242 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5557174 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5549852 | — | IC50 | = | 19400.0 | nM | 4.71 |