Assay Detail
Functional
CHEMBL5516435
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Anti-influenza activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T cells assessed as reduction in virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.71 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | 2.0 | 1 | 8.40 |
| CHEMBL5542746 | — | — | 1 | 7.82 |
| CHEMBL5555922 | — | — | 1 | 7.68 |
| CHEMBL5558188 | — | — | 1 | 7.37 |
| CHEMBL5568372 | — | — | 1 | 7.35 |
| CHEMBL5559114 | — | — | 1 | 7.19 |
| CHEMBL5549877 | — | — | 1 | 7.12 |
| CHEMBL5558310 | — | — | 1 | 6.77 |
| CHEMBL5559715 | — | — | 1 | 6.73 |
| CHEMBL5561667 | — | — | 1 | 6.53 |
| CHEMBL2041442 | — | — | 1 | 6.48 |
| CHEMBL5562237 | — | — | 1 | 6.46 |
| CHEMBL5556759 | — | — | 1 | 6.44 |
| CHEMBL5542247 | — | — | 1 | 6.43 |
| CHEMBL5555111 | — | — | 1 | 6.42 |
| CHEMBL5523627 | — | — | 1 | 6.39 |
| CHEMBL5560887 | — | — | 1 | 6.27 |
| CHEMBL5562396 | — | — | 1 | 6.24 |
| CHEMBL5567281 | — | — | 1 | 6.01 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.75 |
| CHEMBL221722 | FAVIPIRAVIR | 4.0 | 1 | 5.08 |
| CHEMBL5532501 | — | — | 1 | - |
| CHEMBL5542363 | — | — | 1 | - |
| CHEMBL5559029 | — | — | 1 | - |
| CHEMBL5523476 | — | — | 1 | - |
| CHEMBL5532177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5542746 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5555922 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5558188 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5568372 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5559114 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5549877 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5558310 | — | EC50 | = | 169.0 | nM | 6.77 |
| CHEMBL5559715 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL5561667 | — | EC50 | = | 298.0 | nM | 6.53 |
| CHEMBL2041442 | — | EC50 | = | 332.0 | nM | 6.48 |
| CHEMBL5562237 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL5556759 | — | EC50 | = | 365.0 | nM | 6.44 |
| CHEMBL5542247 | — | EC50 | = | 374.0 | nM | 6.43 |
| CHEMBL5555111 | — | EC50 | = | 383.0 | nM | 6.42 |
| CHEMBL5523627 | — | EC50 | = | 407.0 | nM | 6.39 |
| CHEMBL5560887 | — | EC50 | = | 534.0 | nM | 6.27 |
| CHEMBL5562396 | — | EC50 | = | 572.0 | nM | 6.24 |
| CHEMBL5567281 | — | EC50 | = | 974.0 | nM | 6.01 |
| CHEMBL660 | AMANTADINE | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL221722 | FAVIPIRAVIR | EC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL5532501 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5542363 | — | EC50 | > | 44000.0 | nM | - |
| CHEMBL5559029 | — | EC50 | > | 43000.0 | nM | - |
| CHEMBL5523476 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5532177 | — | EC50 | > | 10000.0 | nM | - |