Assay Detail
Binding
CHEMBL5516617
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Inhibition of PARP-1 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Selective PARP-1 Inhibitors and Antitumor Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.69 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 9.15 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 9.10 |
| CHEMBL3930624 | FLUZOPARIB | 3.0 | 1 | 8.84 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 8.30 |
| CHEMBL3606021 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3930624 | FLUZOPARIB | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3606021 | — | IC50 | = | 8.6 | nM | 8.07 |