Assay Detail
Binding
CHEMBL5516902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ROMK expressed in T-REX-CHO cells incubated for 3 to 8 mins by whole cell manual patch clamp assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-REX-CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-sensitive inward rectifier potassium channel 1 (CHEMBL1293292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.88 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561980 | — | — | 1 | 8.33 |
| CHEMBL5560640 | — | — | 1 | 8.24 |
| CHEMBL5563848 | — | — | 1 | 8.17 |
| CHEMBL5558589 | — | — | 1 | 8.10 |
| CHEMBL5556822 | — | — | 1 | 8.09 |
| CHEMBL5560628 | — | — | 1 | 8.03 |
| CHEMBL5559136 | — | — | 1 | 7.96 |
| CHEMBL5563632 | — | — | 1 | 7.92 |
| CHEMBL5560486 | — | — | 1 | 7.89 |
| CHEMBL5560684 | — | — | 1 | 7.80 |
| CHEMBL5527997 | — | — | 1 | 7.75 |
| CHEMBL5565705 | — | — | 1 | 7.66 |
| CHEMBL5561669 | — | — | 1 | 7.60 |
| CHEMBL5558564 | — | — | 1 | 7.43 |
| CHEMBL5517758 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561980 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5560640 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5563848 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5558589 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5556822 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5560628 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5559136 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5563632 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5560486 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5560684 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5527997 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5565705 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5561669 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5558564 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5517758 | — | IC50 | = | 57.0 | nM | 7.24 |