Assay Detail
Toxicity
CHEMBL5516904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in HEK293 cells incubated for 2 to 5 mins by Manual patch clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560486 | — | — | 1 | 8.00 |
| CHEMBL5560628 | — | — | 1 | 6.39 |
| CHEMBL5561980 | — | — | 1 | 5.44 |
| CHEMBL5563848 | — | — | 1 | 4.75 |
| CHEMBL5561669 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560486 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5560628 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5561980 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5563848 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5561669 | — | IC50 | = | 21000.0 | nM | 4.68 |