Assay Detail
Functional
CHEMBL5517420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS CoV-2 spike-pseudotyped lentivirus infected in human A549-hACE2-TMPRSS2 cells assessed as inhibition of viral entry incubated for 24 hrs in absence of BSA by luciferase reporter assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | A549-hACE2-TMPRSS2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Colloidal Aggregation Confounds Cell-Based Covid-19 Antiviral Screens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.56 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449947 | — | — | 1 | 7.16 |
| CHEMBL1214598 | UMIFENOVIR | 3.0 | 1 | 6.58 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.39 |
| CHEMBL463843 | CANNABIGEROLIC ACID | — | 1 | 5.92 |
| CHEMBL289277 | EMODIN | — | 1 | 5.66 |
| CHEMBL262344 | BAKUCHIOL | 1.0 | 1 | 5.27 |
| CHEMBL639 | AZELASTINE | 4.0 | 1 | 4.57 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 4.46 |
| CHEMBL286494 | HYPERICIN | 3.0 | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449947 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1214598 | UMIFENOVIR | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1336 | SORAFENIB | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL463843 | CANNABIGEROLIC ACID | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL289277 | EMODIN | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL262344 | BAKUCHIOL | EC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL639 | AZELASTINE | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | EC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL286494 | HYPERICIN | EC50 | = | 84400.0 | nM | 4.07 |