Assay Detail
Functional
CHEMBL5517428
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Antiviral activity against luciferase independent SARS CoV-2 spike-pseudotyped lentivirus infected in human A549-hACE2-TMPRSS2 cells assessed as inhibition of viral entry measured after 24 hrs before centrifugation by luciferase reporter assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | A549-hACE2-TMPRSS2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Colloidal Aggregation Confounds Cell-Based Covid-19 Antiviral Screens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.94 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 6.72 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 6.57 |
| CHEMBL1214598 | UMIFENOVIR | 3.0 | 1 | 6.36 |
| CHEMBL289277 | EMODIN | — | 1 | 5.65 |
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | 5.58 |
| CHEMBL639 | AZELASTINE | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1336 | SORAFENIB | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1214598 | UMIFENOVIR | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL289277 | EMODIN | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL441687 | GLYCYRRHIZIN | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL639 | AZELASTINE | EC50 | = | 18700.0 | nM | 4.73 |