Assay Detail
Functional
CHEMBL5517434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 pseudotyped lentivirus infected in HEK293 cells overexpressing EGFP-fused hACE2 coexpressing mCherry assessed as reduction in virus entry incubated for 40 mins by immunocytochemistry assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Colloidal Aggregation Confounds Cell-Based Covid-19 Antiviral Screens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.29 | 4.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253467 | ISOBAVACHALCONE | — | 1 | 4.29 |
| CHEMBL262344 | BAKUCHIOL | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253467 | ISOBAVACHALCONE | EC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL262344 | BAKUCHIOL | EC50 | = | 110000.0 | nM | - |