Assay Detail
Binding
CHEMBL5518259
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Inhibition of HIV-1 RNase H
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.48 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556623 | — | — | 1 | 6.19 |
| CHEMBL5523421 | — | — | 1 | 5.89 |
| CHEMBL1958265 | — | — | 1 | 5.70 |
| CHEMBL3409201 | — | — | 1 | 5.60 |
| CHEMBL5560231 | — | — | 1 | 5.52 |
| CHEMBL5557831 | — | — | 1 | 5.35 |
| CHEMBL5560779 | — | — | 1 | 5.22 |
| CHEMBL5523578 | — | — | 1 | 5.00 |
| CHEMBL1233795 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556623 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5523421 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1958265 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3409201 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5560231 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5557831 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5560779 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5523578 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1233795 | — | IC50 | = | 15000.0 | nM | 4.82 |