Assay Detail
Binding
CHEMBL5518267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Recent advances on dual inhibitors targeting HIV reverse transcriptase associated polymerase and ribonuclease H.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.66 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557278 | — | — | 1 | 4.79 |
| CHEMBL5559592 | — | — | 1 | 4.77 |
| CHEMBL5557641 | — | — | 1 | 4.69 |
| CHEMBL5556460 | — | — | 1 | 4.40 |
| CHEMBL5173438 | — | — | 1 | - |
| CHEMBL5566125 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557278 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5559592 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5557641 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL5556460 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL5173438 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5566125 | — | IC50 | > | 100000.0 | nM | - |