Assay Detail
Binding
CHEMBL5518290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.20 | 9.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260316 | — | — | 1 | 9.76 |
| CHEMBL3586462 | — | — | 1 | 8.49 |
| CHEMBL5543015 | — | — | 1 | 7.87 |
| CHEMBL4065412 | — | — | 1 | 7.51 |
| CHEMBL5542641 | — | — | 1 | 7.38 |
| CHEMBL4092869 | — | — | 1 | 6.94 |
| CHEMBL4868614 | — | — | 1 | 6.82 |
| CHEMBL5202802 | — | — | 1 | 6.74 |
| CHEMBL5557739 | — | — | 1 | 6.31 |
| CHEMBL5557597 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260316 | — | IC50 | = | 0.174 | nM | 9.76 |
| CHEMBL3586462 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5543015 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4065412 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5542641 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL4092869 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4868614 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5202802 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5557739 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5557597 | — | IC50 | = | 63000.0 | nM | 4.20 |