Assay Detail
Functional
CHEMBL5519236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-30 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel coumarin-based derivatives as inhibitors of tubulin polymerization targeting the colchicine binding site with potent anti-gastric cancer activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.99 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561294 | — | — | 1 | 7.47 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.17 |
| CHEMBL5560931 | — | — | 1 | 6.82 |
| CHEMBL5561427 | — | — | 1 | 6.72 |
| CHEMBL5568018 | — | — | 1 | 6.40 |
| CHEMBL5567791 | — | — | 1 | 6.17 |
| CHEMBL5561342 | — | — | 1 | 6.06 |
| CHEMBL5558941 | — | — | 1 | 5.82 |
| CHEMBL5568207 | — | — | 1 | 5.71 |
| CHEMBL5565149 | — | — | 1 | 5.66 |
| CHEMBL5568530 | — | — | 1 | 5.14 |
| CHEMBL5559470 | — | — | 1 | 5.04 |
| CHEMBL5561932 | — | — | 1 | 4.88 |
| CHEMBL5560112 | — | — | 1 | 4.77 |
| CHEMBL5568099 | — | — | 1 | - |
| CHEMBL5568230 | — | — | 1 | - |
| CHEMBL5560553 | — | — | 1 | - |
| CHEMBL5558956 | — | — | 1 | - |
| CHEMBL367262 | — | — | 1 | - |
| CHEMBL1418970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561294 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL107 | COLCHICINE | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5560931 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5561427 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5568018 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5567791 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5561342 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5558941 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5568207 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5565149 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL5568530 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL5559470 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL5561932 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5560112 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL5568099 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5568230 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5560553 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5558956 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL367262 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1418970 | — | IC50 | > | 20000.0 | nM | - |