Assay Detail
Functional
CHEMBL5519574
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Antiproliferative activity against human HCC827 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.84 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 8.52 |
| CHEMBL5542997 | — | — | 1 | 7.60 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.52 |
| CHEMBL5563885 | — | — | 1 | 7.51 |
| CHEMBL5557331 | — | — | 1 | 7.50 |
| CHEMBL5542265 | — | — | 1 | 7.48 |
| CHEMBL5566626 | — | — | 1 | 7.43 |
| CHEMBL5561396 | — | — | 1 | 7.35 |
| CHEMBL5561820 | — | — | 1 | 7.32 |
| CHEMBL5565260 | — | — | 1 | 7.26 |
| CHEMBL5561097 | — | — | 1 | 7.16 |
| CHEMBL5564914 | — | — | 1 | 7.16 |
| CHEMBL5565643 | — | — | 1 | 6.64 |
| CHEMBL5562212 | — | — | 1 | 6.47 |
| CHEMBL5555297 | — | — | 1 | 6.46 |
| CHEMBL5542295 | — | — | 1 | 6.37 |
| CHEMBL5542644 | — | — | 1 | 6.33 |
| CHEMBL5567974 | — | — | 1 | 6.33 |
| CHEMBL5564639 | — | — | 1 | 6.23 |
| CHEMBL5523515 | — | — | 1 | 6.05 |
| CHEMBL5556967 | — | — | 1 | 5.77 |
| CHEMBL5555443 | — | — | 1 | 5.49 |
| CHEMBL5542659 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5542997 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5563885 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5557331 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5542265 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5566626 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5561396 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5561820 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5565260 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5561097 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5564914 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5565643 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5562212 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL5555297 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL5542295 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL5542644 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL5567974 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL5564639 | — | IC50 | = | 584.0 | nM | 6.23 |
| CHEMBL5523515 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL5556967 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5555443 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL5542659 | — | IC50 | = | 4340.0 | nM | 5.36 |