Assay Detail
Functional
CHEMBL5519638
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Antiproliferative activity against human A549 cells incubated for 72 hrs
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.50 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.30 |
| CHEMBL5559529 | — | — | 1 | 8.00 |
| CHEMBL5560424 | — | — | 1 | 7.92 |
| CHEMBL5562001 | — | — | 1 | 7.72 |
| CHEMBL5563800 | — | — | 1 | 6.43 |
| CHEMBL5549800 | — | — | 1 | 6.33 |
| CHEMBL5565213 | — | — | 1 | 6.26 |
| CHEMBL5555894 | — | — | 1 | 5.75 |
| CHEMBL5559483 | — | — | 1 | 5.74 |
| CHEMBL5542417 | — | — | 1 | 5.61 |
| CHEMBL5542200 | — | — | 1 | 5.56 |
| CHEMBL5566922 | — | — | 1 | 5.43 |
| CHEMBL5559137 | — | — | 1 | 5.41 |
| CHEMBL5568500 | — | — | 1 | - |
| CHEMBL5557986 | — | — | 1 | - |
| CHEMBL5542736 | — | — | 1 | - |
| CHEMBL5556632 | — | — | 1 | - |
| CHEMBL5559164 | — | — | 1 | - |
| CHEMBL5560260 | — | — | 1 | - |
| CHEMBL5556498 | — | — | 1 | - |
| CHEMBL5560499 | — | — | 1 | - |
| CHEMBL5542218 | — | — | 1 | - |
| CHEMBL5563040 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5559529 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5560424 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5562001 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5563800 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL5549800 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL5565213 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL5555894 | — | IC50 | = | 1758.0 | nM | 5.75 |
| CHEMBL5559483 | — | IC50 | = | 1834.0 | nM | 5.74 |
| CHEMBL5542417 | — | IC50 | = | 2441.0 | nM | 5.61 |
| CHEMBL5542200 | — | IC50 | = | 2762.0 | nM | 5.56 |
| CHEMBL5566922 | — | IC50 | = | 3753.0 | nM | 5.43 |
| CHEMBL5559137 | — | IC50 | = | 3904.0 | nM | 5.41 |
| CHEMBL5568500 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5557986 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5542736 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5556632 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5559164 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5560260 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5556498 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5560499 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5542218 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5563040 | — | IC50 | > | 5000.0 | nM | - |