Assay Detail
Functional
CHEMBL5519642
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Antiproliferative activity against human U-937 cells incubated for 72 hrs
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.94 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.52 |
| CHEMBL5562001 | — | — | 1 | 8.22 |
| CHEMBL5559529 | — | — | 1 | 7.75 |
| CHEMBL5560424 | — | — | 1 | 7.66 |
| CHEMBL5563800 | — | — | 1 | 6.10 |
| CHEMBL5563040 | — | — | 1 | 5.79 |
| CHEMBL5565213 | — | — | 1 | 5.37 |
| CHEMBL5549800 | — | — | 1 | 5.07 |
| CHEMBL5559137 | — | — | 1 | - |
| CHEMBL5559483 | — | — | 1 | - |
| CHEMBL5542417 | — | — | 1 | - |
| CHEMBL5555894 | — | — | 1 | - |
| CHEMBL5568500 | — | — | 1 | - |
| CHEMBL5566922 | — | — | 1 | - |
| CHEMBL5542736 | — | — | 1 | - |
| CHEMBL5556632 | — | — | 1 | - |
| CHEMBL5559164 | — | — | 1 | - |
| CHEMBL5560260 | — | — | 1 | - |
| CHEMBL5556498 | — | — | 1 | - |
| CHEMBL5560499 | — | — | 1 | - |
| CHEMBL5542218 | — | — | 1 | - |
| CHEMBL5542200 | — | — | 1 | - |
| CHEMBL5557986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5562001 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5559529 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5560424 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5563800 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5563040 | — | IC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL5565213 | — | IC50 | = | 4316.0 | nM | 5.37 |
| CHEMBL5549800 | — | IC50 | = | 8594.0 | nM | 5.07 |
| CHEMBL5559137 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5559483 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5542417 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5555894 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5568500 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5566922 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5542736 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5556632 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5559164 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5560260 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5556498 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5560499 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5542218 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5542200 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5557986 | — | IC50 | > | 5000.0 | nM | - |