Assay Detail
Functional
CHEMBL5519692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell growth in human A549/Taxol cells incubated for 72 hrs by SRB method
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549/TR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.15 | 8.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5559529 | — | — | 2 | 8.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5559529 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1029.0 | nM | 5.99 |
| CHEMBL5559529 | — | Inhibition | - | % | - |