Assay Detail
Binding
CHEMBL5519781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RIPK1 (unknown origin) in presence of ATP by kinaseProfiler assay
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 58 | 6.93 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556218 | — | — | 1 | 7.37 |
| CHEMBL5561181 | — | — | 1 | 7.35 |
| CHEMBL5567000 | — | — | 1 | 7.31 |
| CHEMBL5556266 | — | — | 1 | 7.22 |
| CHEMBL5558782 | — | — | 1 | 7.22 |
| CHEMBL5564024 | — | — | 1 | 7.19 |
| CHEMBL5565474 | — | — | 1 | 7.18 |
| CHEMBL5532440 | — | — | 1 | 7.17 |
| CHEMBL5532126 | — | — | 1 | 7.15 |
| CHEMBL5564745 | — | — | 1 | 7.13 |
| CHEMBL5532312 | — | — | 1 | 7.10 |
| CHEMBL5568571 | — | — | 1 | 7.09 |
| CHEMBL5561911 | — | — | 1 | 7.09 |
| CHEMBL5550041 | — | — | 1 | 7.07 |
| CHEMBL5563271 | — | — | 1 | 7.02 |
| CHEMBL5562516 | — | — | 1 | 7.01 |
| CHEMBL5556717 | — | — | 1 | 7.01 |
| CHEMBL5557333 | — | — | 1 | 6.99 |
| CHEMBL5560163 | — | — | 1 | 6.98 |
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 6.97 |
| CHEMBL5561992 | — | — | 1 | 6.96 |
| CHEMBL5566975 | — | — | 1 | 6.96 |
| CHEMBL5565161 | — | — | 1 | 6.96 |
| CHEMBL5561482 | — | — | 1 | 6.95 |
| CHEMBL5562264 | — | — | 1 | 6.94 |
| CHEMBL5561695 | — | — | 1 | 6.92 |
| CHEMBL5558101 | — | — | 1 | 6.90 |
| CHEMBL5556955 | — | — | 1 | 6.88 |
| CHEMBL5567942 | — | — | 1 | 6.87 |
| CHEMBL5562564 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556218 | — | IC50 | = | 42.7 | nM | 7.37 |
| CHEMBL5561181 | — | IC50 | = | 44.7 | nM | 7.35 |
| CHEMBL5567000 | — | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL5556266 | — | IC50 | = | 59.8 | nM | 7.22 |
| CHEMBL5558782 | — | IC50 | = | 60.5 | nM | 7.22 |
| CHEMBL5564024 | — | IC50 | = | 64.3 | nM | 7.19 |
| CHEMBL5565474 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL5532440 | — | IC50 | = | 68.4 | nM | 7.17 |
| CHEMBL5532126 | — | IC50 | = | 70.3 | nM | 7.15 |
| CHEMBL5564745 | — | IC50 | = | 73.7 | nM | 7.13 |
| CHEMBL5532312 | — | IC50 | = | 79.8 | nM | 7.10 |
| CHEMBL5568571 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL5561911 | — | IC50 | = | 81.6 | nM | 7.09 |
| CHEMBL5550041 | — | IC50 | = | 84.5 | nM | 7.07 |
| CHEMBL5563271 | — | IC50 | = | 95.9 | nM | 7.02 |
| CHEMBL5562516 | — | IC50 | = | 97.6 | nM | 7.01 |
| CHEMBL5556717 | — | IC50 | = | 98.7 | nM | 7.01 |
| CHEMBL5557333 | — | IC50 | = | 101.7 | nM | 6.99 |
| CHEMBL5560163 | — | IC50 | = | 105.4 | nM | 6.98 |
| CHEMBL4071864 | GSK2982772 | IC50 | = | 107.4 | nM | 6.97 |
| CHEMBL5561992 | — | IC50 | = | 110.3 | nM | 6.96 |
| CHEMBL5566975 | — | IC50 | = | 108.9 | nM | 6.96 |
| CHEMBL5565161 | — | IC50 | = | 110.7 | nM | 6.96 |
| CHEMBL5561482 | — | IC50 | = | 112.3 | nM | 6.95 |
| CHEMBL5562264 | — | IC50 | = | 113.8 | nM | 6.94 |
| CHEMBL5561695 | — | IC50 | = | 119.5 | nM | 6.92 |
| CHEMBL5558101 | — | IC50 | = | 124.6 | nM | 6.90 |
| CHEMBL5556955 | — | IC50 | = | 133.2 | nM | 6.88 |
| CHEMBL5567942 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5562564 | — | IC50 | = | 140.2 | nM | 6.85 |
| CHEMBL5543043 | — | IC50 | = | 149.1 | nM | 6.83 |
| CHEMBL5549905 | — | IC50 | = | 157.5 | nM | 6.80 |
| CHEMBL5555219 | — | IC50 | = | 176.5 | nM | 6.75 |
| CHEMBL5567888 | — | IC50 | = | 190.9 | nM | 6.72 |
| CHEMBL5566463 | — | IC50 | = | 290.3 | nM | 6.54 |
| CHEMBL5567917 | — | IC50 | = | 474.9 | nM | 6.32 |
| CHEMBL5558270 | — | IC50 | = | 512.4 | nM | 6.29 |
| CHEMBL5555081 | — | IC50 | = | 915.2 | nM | 6.04 |
| CHEMBL5560802 | — | IC50 | = | 940.7 | nM | 6.03 |
| CHEMBL5563845 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5560728 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5542785 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5555274 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5568148 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5542791 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5558606 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5561817 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5555294 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5568582 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5567207 | — | IC50 | > | 1000.0 | nM | - |