Assay Detail
Functional
CHEMBL5519782
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-necroptosis activity against TSZ-induced human HT-29 cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 7.55 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561181 | — | — | 1 | 8.79 |
| CHEMBL5561992 | — | — | 1 | 8.58 |
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 8.56 |
| CHEMBL5568571 | — | — | 1 | 8.35 |
| CHEMBL5556266 | — | — | 1 | 8.34 |
| CHEMBL5562516 | — | — | 1 | 8.34 |
| CHEMBL5558782 | — | — | 1 | 8.26 |
| CHEMBL5532312 | — | — | 1 | 8.25 |
| CHEMBL5566975 | — | — | 1 | 8.24 |
| CHEMBL5558101 | — | — | 1 | 8.22 |
| CHEMBL5556955 | — | — | 1 | 8.21 |
| CHEMBL5561695 | — | — | 1 | 8.16 |
| CHEMBL5565474 | — | — | 1 | 8.11 |
| CHEMBL5560163 | — | — | 1 | 8.09 |
| CHEMBL5562264 | — | — | 1 | 8.08 |
| CHEMBL5564024 | — | — | 1 | 7.95 |
| CHEMBL5567942 | — | — | 1 | 7.95 |
| CHEMBL5564745 | — | — | 1 | 7.82 |
| CHEMBL5563271 | — | — | 1 | 7.80 |
| CHEMBL5550041 | — | — | 1 | 7.80 |
| CHEMBL5556218 | — | — | 1 | 7.79 |
| CHEMBL5561911 | — | — | 1 | 7.74 |
| CHEMBL5532126 | — | — | 1 | 7.74 |
| CHEMBL5565161 | — | — | 1 | 7.71 |
| CHEMBL5562564 | — | — | 1 | 7.67 |
| CHEMBL5567000 | — | — | 1 | 7.48 |
| CHEMBL5532440 | — | — | 1 | 7.47 |
| CHEMBL5556717 | — | — | 1 | 7.43 |
| CHEMBL5558270 | — | — | 1 | 7.20 |
| CHEMBL5543043 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561181 | — | EC50 | = | 1.61 | nM | 8.79 |
| CHEMBL5561992 | — | EC50 | = | 2.61 | nM | 8.58 |
| CHEMBL4071864 | GSK2982772 | EC50 | = | 2.78 | nM | 8.56 |
| CHEMBL5568571 | — | EC50 | = | 4.45 | nM | 8.35 |
| CHEMBL5556266 | — | EC50 | = | 4.58 | nM | 8.34 |
| CHEMBL5562516 | — | EC50 | = | 4.62 | nM | 8.34 |
| CHEMBL5558782 | — | EC50 | = | 5.45 | nM | 8.26 |
| CHEMBL5532312 | — | EC50 | = | 5.57 | nM | 8.25 |
| CHEMBL5566975 | — | EC50 | = | 5.78 | nM | 8.24 |
| CHEMBL5558101 | — | EC50 | = | 6.01 | nM | 8.22 |
| CHEMBL5556955 | — | EC50 | = | 6.19 | nM | 8.21 |
| CHEMBL5561695 | — | EC50 | = | 6.84 | nM | 8.16 |
| CHEMBL5565474 | — | EC50 | = | 7.73 | nM | 8.11 |
| CHEMBL5560163 | — | EC50 | = | 8.23 | nM | 8.09 |
| CHEMBL5562264 | — | EC50 | = | 8.24 | nM | 8.08 |
| CHEMBL5564024 | — | EC50 | = | 11.26 | nM | 7.95 |
| CHEMBL5567942 | — | EC50 | = | 11.29 | nM | 7.95 |
| CHEMBL5564745 | — | EC50 | = | 15.1 | nM | 7.82 |
| CHEMBL5563271 | — | EC50 | = | 15.74 | nM | 7.80 |
| CHEMBL5550041 | — | EC50 | = | 15.99 | nM | 7.80 |
| CHEMBL5556218 | — | EC50 | = | 16.12 | nM | 7.79 |
| CHEMBL5561911 | — | EC50 | = | 18.36 | nM | 7.74 |
| CHEMBL5532126 | — | EC50 | = | 18.21 | nM | 7.74 |
| CHEMBL5565161 | — | EC50 | = | 19.29 | nM | 7.71 |
| CHEMBL5562564 | — | EC50 | = | 21.44 | nM | 7.67 |
| CHEMBL5567000 | — | EC50 | = | 32.99 | nM | 7.48 |
| CHEMBL5532440 | — | EC50 | = | 33.95 | nM | 7.47 |
| CHEMBL5556717 | — | EC50 | = | 37.45 | nM | 7.43 |
| CHEMBL5558270 | — | EC50 | = | 62.98 | nM | 7.20 |
| CHEMBL5543043 | — | EC50 | = | 107.7 | nM | 6.97 |
| CHEMBL5562358 | — | EC50 | = | 134.3 | nM | 6.87 |
| CHEMBL5567888 | — | EC50 | = | 148.9 | nM | 6.83 |
| CHEMBL5561821 | — | EC50 | = | 246.5 | nM | 6.61 |
| CHEMBL5566463 | — | EC50 | = | 256.9 | nM | 6.59 |
| CHEMBL5567917 | — | EC50 | = | 331.0 | nM | 6.48 |
| CHEMBL5568582 | — | EC50 | = | 545.8 | nM | 6.26 |
| CHEMBL5555081 | — | EC50 | = | 562.4 | nM | 6.25 |
| CHEMBL5558020 | — | EC50 | = | 578.6 | nM | 6.24 |
| CHEMBL5532448 | — | EC50 | = | 597.4 | nM | 6.22 |
| CHEMBL5563845 | — | EC50 | = | 891.34 | nM | 6.05 |
| CHEMBL5560802 | — | EC50 | = | 904.9 | nM | 6.04 |
| CHEMBL5567207 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5555294 | — | EC50 | - | — | - | |
| CHEMBL5558543 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5555274 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5562899 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5556217 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5561817 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5565083 | — | EC50 | - | — | - | |
| CHEMBL5555219 | — | EC50 | > | 1000.0 | nM | - |