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Assay Detail

CHEMBL5519783

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Functional
Anti-necroptosis activity against TSZ-induced human U-937 cells
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Autocuration

Target

U-937 (CHEMBL612794) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.
Zhang C, Chen Y, Li Y, Shi N, Teng Y, Li N, Tang M, Ma Z, Deng D, Chen L.
Eur J Med Chem (2024) 265 : 116076 -116076
PubMed 38171150 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 50 7.62 9.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5561695 — — 1 9.34
CHEMBL4071864 GSK2982772 2.0 1 8.90
CHEMBL5567942 — — 1 8.86
CHEMBL5558782 — — 1 8.76
CHEMBL5558101 — — 1 8.73
CHEMBL5561181 — — 1 8.73
CHEMBL5532440 — — 1 8.73
CHEMBL5556266 — — 1 8.51
CHEMBL5566975 — — 1 8.43
CHEMBL5532312 — — 1 8.41
CHEMBL5561992 — — 1 8.41
CHEMBL5532126 — — 1 8.39
CHEMBL5556218 — — 1 8.35
CHEMBL5561911 — — 1 8.33
CHEMBL5562516 — — 1 8.32
CHEMBL5564745 — — 1 8.29
CHEMBL5568571 — — 1 8.08
CHEMBL5556955 — — 1 8.01
CHEMBL5556717 — — 1 7.99
CHEMBL5563271 — — 1 7.90
CHEMBL5550041 — — 1 7.83
CHEMBL5560163 — — 1 7.81
CHEMBL5565474 — — 1 7.76
CHEMBL5562264 — — 1 7.73
CHEMBL5567000 — — 1 7.66
CHEMBL5564024 — — 1 7.64
CHEMBL5565161 — — 1 7.48
CHEMBL5562564 — — 1 7.43
CHEMBL5562358 — — 1 7.22
CHEMBL5561821 — — 1 6.99

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5561695 — EC50 = 0.46 nM 9.34
CHEMBL4071864 GSK2982772 EC50 = 1.27 nM 8.90
CHEMBL5567942 — EC50 = 1.38 nM 8.86
CHEMBL5558782 — EC50 = 1.74 nM 8.76
CHEMBL5558101 — EC50 = 1.88 nM 8.73
CHEMBL5561181 — EC50 = 1.84 nM 8.73
CHEMBL5532440 — EC50 = 1.87 nM 8.73
CHEMBL5556266 — EC50 = 3.09 nM 8.51
CHEMBL5566975 — EC50 = 3.68 nM 8.43
CHEMBL5532312 — EC50 = 3.9 nM 8.41
CHEMBL5561992 — EC50 = 3.89 nM 8.41
CHEMBL5532126 — EC50 = 4.04 nM 8.39
CHEMBL5556218 — EC50 = 4.45 nM 8.35
CHEMBL5561911 — EC50 = 4.64 nM 8.33
CHEMBL5562516 — EC50 = 4.82 nM 8.32
CHEMBL5564745 — EC50 = 5.09 nM 8.29
CHEMBL5568571 — EC50 = 8.29 nM 8.08
CHEMBL5556955 — EC50 = 9.75 nM 8.01
CHEMBL5556717 — EC50 = 10.19 nM 7.99
CHEMBL5563271 — EC50 = 12.72 nM 7.90
CHEMBL5550041 — EC50 = 14.61 nM 7.83
CHEMBL5560163 — EC50 = 15.48 nM 7.81
CHEMBL5565474 — EC50 = 17.34 nM 7.76
CHEMBL5562264 — EC50 = 18.48 nM 7.73
CHEMBL5567000 — EC50 = 22.02 nM 7.66
CHEMBL5564024 — EC50 = 22.66 nM 7.64
CHEMBL5565161 — EC50 = 32.97 nM 7.48
CHEMBL5562564 — EC50 = 37.08 nM 7.43
CHEMBL5562358 — EC50 = 60.13 nM 7.22
CHEMBL5561821 — EC50 = 103.44 nM 6.99
CHEMBL5566463 — EC50 = 111.7 nM 6.95
CHEMBL5543043 — EC50 = 116.75 nM 6.93
CHEMBL5558270 — EC50 = 173.4 nM 6.76
CHEMBL5567888 — EC50 = 232.1 nM 6.63
CHEMBL5567917 — EC50 = 282.6 nM 6.55
CHEMBL5555219 — EC50 = 638.1 nM 6.20
CHEMBL5555081 — EC50 = 702.93 nM 6.15
CHEMBL5532448 — EC50 = 721.85 nM 6.14
CHEMBL5560802 — EC50 = 811.8 nM 6.09
CHEMBL5563845 — EC50 = 878.72 nM 6.06
CHEMBL5558020 — EC50 = 945.7 nM 6.02
CHEMBL5567207 — EC50 = 990.2 nM 6.00
CHEMBL5568582 — EC50 = 1025.0 nM 5.99
CHEMBL5565083 — EC50 - — -
CHEMBL5555294 — EC50 - — -
CHEMBL5558543 — EC50 > 1000.0 nM -
CHEMBL5555274 — EC50 > 1000.0 nM -
CHEMBL5561817 — EC50 > 1000.0 nM -
CHEMBL5556217 — EC50 > 1000.0 nM -
CHEMBL5562899 — EC50 > 1000.0 nM -