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Assay Detail

CHEMBL5519829

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Functional
Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell growth measured after 48 hrs by CCK8 method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KYSE-30
Confidence 1 — Organism
Curated By Autocuration

Target

KYSE-30 (CHEMBL4513130)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of 1,2,3-triazole benzothiazole derivatives as tubulin polymerization inhibitors with potent anti-esophageal cancer activities.
Wu BW, Huang WJ, Liu YH, Liu QG, Song J, Hu T, Chen P, Zhang SY.
Eur J Med Chem (2024) 265 : 116118 -116118
PubMed 38181651 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.84 7.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5557246 1 7.38
CHEMBL107 COLCHICINE 4.0 1 7.32
CHEMBL5557369 1 7.31
CHEMBL5566505 1 7.24
CHEMBL5560699 1 7.23
CHEMBL5568125 1 7.17
CHEMBL5559996 1 7.14
CHEMBL5566802 1 6.12
CHEMBL5561209 1 5.94
CHEMBL4594078 1 5.84
CHEMBL5566273 1 5.76
CHEMBL5559727 1 5.73
CHEMBL5560966 1 4.92
CHEMBL5562410 1 4.55
CHEMBL5567641 1 4.45
CHEMBL5557253 1 4.25
CHEMBL5562836 1 4.21
CHEMBL5561989 1 4.20
CHEMBL5567915 1 4.11
CHEMBL5523609 1 -
CHEMBL5557176 1 -
CHEMBL5563325 1 -
CHEMBL5567947 1 -
CHEMBL5558145 1 -
CHEMBL5563888 1 -
CHEMBL5560578 1 -
CHEMBL5556287 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5557246 IC50 = 42.0 nM 7.38
CHEMBL107 COLCHICINE IC50 = 48.0 nM 7.32
CHEMBL5557369 IC50 = 49.0 nM 7.31
CHEMBL5566505 IC50 = 58.0 nM 7.24
CHEMBL5560699 IC50 = 59.0 nM 7.23
CHEMBL5568125 IC50 = 67.0 nM 7.17
CHEMBL5559996 IC50 = 72.0 nM 7.14
CHEMBL5566802 IC50 = 760.0 nM 6.12
CHEMBL5561209 IC50 = 1140.0 nM 5.94
CHEMBL4594078 IC50 = 1440.0 nM 5.84
CHEMBL5566273 IC50 = 1740.0 nM 5.76
CHEMBL5559727 IC50 = 1860.0 nM 5.73
CHEMBL5560966 IC50 = 12100.0 nM 4.92
CHEMBL5562410 IC50 = 28280.0 nM 4.55
CHEMBL5567641 IC50 = 35540.0 nM 4.45
CHEMBL5557253 IC50 = 56800.0 nM 4.25
CHEMBL5562836 IC50 = 62240.0 nM 4.21
CHEMBL5561989 IC50 = 63120.0 nM 4.20
CHEMBL5567915 IC50 = 77620.0 nM 4.11
CHEMBL5523609 IC50 > 80000.0 nM -
CHEMBL5557176 IC50 > 80000.0 nM -
CHEMBL5563325 IC50 > 80000.0 nM -
CHEMBL5567947 IC50 > 80000.0 nM -
CHEMBL5558145 IC50 > 80000.0 nM -
CHEMBL5563888 IC50 > 80000.0 nM -
CHEMBL5560578 IC50 > 80000.0 nM -
CHEMBL5556287 IC50 > 80000.0 nM -