Assay Detail
Binding
CHEMBL5519925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to mTORC1 (unknown origin) assessed as apparent inhibition constant in presence of ATP by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.19 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 9.74 |
| CHEMBL1091978 | — | — | 1 | 7.68 |
| CHEMBL3813842 | PAXALISIB | 2.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL1091978 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3813842 | PAXALISIB | Ki | = | 70.0 | nM | 7.16 |