Assay Detail
Binding
CHEMBL5520039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at TRPC3 (unknown origin) assessed as inhibition of channel activity
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 3 (CHEMBL2417348) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.41 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2418811 | — | — | 1 | 8.52 |
| CHEMBL2418809 | — | — | 1 | 8.30 |
| CHEMBL5558723 | — | — | 1 | 8.00 |
| CHEMBL4177187 | — | — | 1 | 6.16 |
| CHEMBL5532633 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2418811 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2418809 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5558723 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4177187 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5532633 | — | IC50 | = | 840.0 | nM | 6.08 |