Assay Detail
Binding
CHEMBL5520268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to tau (unknown origin) preformed fibrils assessed as dissociation constant by FP assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Microtubule-associated protein tau (CHEMBL1293224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.58 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330529 | — | — | 1 | 5.59 |
| CHEMBL5562482 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330529 | — | Kd | = | 2550.0 | nM | 5.59 |
| CHEMBL5562482 | — | Kd | = | 2780.0 | nM | 5.56 |