Assay Detail
Binding
CHEMBL5520491
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Inhibition of his6-tagged L1 (unknown origin) expressed in Escherichia coli BL21-DE3 incubated for 16 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.04 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5542695 | — | — | 1 | 6.21 |
| CHEMBL5561352 | — | — | 1 | 6.17 |
| CHEMBL5560118 | — | — | 1 | 5.31 |
| CHEMBL5562130 | — | — | 1 | 5.27 |
| CHEMBL5542518 | — | — | 1 | 5.16 |
| CHEMBL5555228 | — | — | 1 | 5.11 |
| CHEMBL5558893 | — | — | 1 | 5.05 |
| CHEMBL5560033 | — | — | 1 | 4.92 |
| CHEMBL5560561 | — | — | 1 | 4.82 |
| CHEMBL4639950 | — | — | 1 | 4.66 |
| CHEMBL5559815 | — | — | 1 | 4.62 |
| CHEMBL5558940 | — | — | 1 | 4.52 |
| CHEMBL5568533 | — | — | 1 | 4.50 |
| CHEMBL5543053 | — | — | 1 | 4.24 |
| CHEMBL5558614 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5542695 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5561352 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5560118 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5562130 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5542518 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5555228 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5558893 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5560033 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5560561 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4639950 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5559815 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5558940 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5568533 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5543053 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL5558614 | — | IC50 | - | — | - |