Assay Detail
Binding
CHEMBL5520552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PARP1 incubated for 90 mins by colorimetric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Proof of Concept of Potent Dual Polθ/PARP Inhibitors for Efficient Treatment of Homologous Recombination-Deficient Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.67 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 9.40 |
| CHEMBL5556723 | — | — | 1 | 8.33 |
| CHEMBL5558410 | — | — | 1 | 8.27 |
| CHEMBL5564238 | — | — | 1 | - |
| CHEMBL5555891 | — | — | 1 | - |
| CHEMBL5566472 | — | — | 1 | - |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521686 | OLAPARIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5556723 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5558410 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5564238 | — | IC50 | - | — | - | |
| CHEMBL5555891 | — | IC50 | - | — | - | |
| CHEMBL5566472 | — | IC50 | - | — | - | |
| CHEMBL36506 | NOVOBIOCIN | IC50 | - | — | - |