Assay Detail
Binding
CHEMBL5520840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST tagged NDM-1 (unknown origin) expressed in Escherichia coli BL21 Star (DE3) competent cells using CCF2-FA as substrate incubated for 2 hrs by fluorescence based analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.66 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560688 | — | — | 1 | 10.40 |
| CHEMBL5557291 | — | — | 1 | 10.00 |
| CHEMBL5561531 | — | — | 1 | 10.00 |
| CHEMBL5558966 | — | — | 1 | 9.70 |
| CHEMBL5562489 | — | — | 1 | 9.52 |
| CHEMBL5557976 | — | — | 1 | 9.15 |
| CHEMBL5562433 | — | — | 1 | 9.10 |
| CHEMBL5564330 | — | — | 1 | 9.10 |
| CHEMBL5566592 | — | — | 1 | 9.05 |
| CHEMBL5560177 | — | — | 1 | 8.96 |
| CHEMBL5555996 | — | — | 1 | 8.64 |
| CHEMBL5542703 | — | — | 1 | 8.57 |
| CHEMBL5284444 | — | — | 1 | 8.43 |
| CHEMBL5557107 | — | — | 1 | 8.41 |
| CHEMBL5564168 | — | — | 1 | 8.40 |
| CHEMBL5562403 | — | — | 1 | 8.30 |
| CHEMBL5562757 | — | — | 1 | 8.22 |
| CHEMBL5559568 | — | — | 1 | 8.19 |
| CHEMBL5560114 | — | — | 1 | 8.03 |
| CHEMBL5558088 | — | — | 1 | 7.96 |
| CHEMBL5555936 | — | — | 1 | 7.96 |
| CHEMBL5558856 | — | — | 1 | 7.96 |
| CHEMBL5562205 | — | — | 1 | 7.92 |
| CHEMBL5565123 | — | — | 1 | 7.87 |
| CHEMBL5560620 | — | — | 1 | 7.76 |
| CHEMBL5559133 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560688 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5557291 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5561531 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5558966 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5562489 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5557976 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5562433 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5564330 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5566592 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5560177 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5555996 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5542703 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5284444 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5557107 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5564168 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5562403 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5562757 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5559568 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5560114 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5558088 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5555936 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5558856 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5562205 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5565123 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL5560620 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL5559133 | — | IC50 | = | 31.0 | nM | 7.51 |