Assay Detail
Binding
CHEMBL5522372
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Inhibition of CLK2 (unknown origin) incubated for 10 mins in presence of ATP
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.80 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561941 | — | — | 1 | 8.85 |
| CHEMBL5560595 | — | — | 1 | 8.43 |
| CHEMBL5563432 | — | — | 1 | 8.25 |
| CHEMBL5559906 | — | — | 1 | 8.17 |
| CHEMBL5558849 | — | — | 1 | 8.12 |
| CHEMBL4297639 | LORECIVIVINT | 3.0 | 1 | 8.11 |
| CHEMBL5559654 | — | — | 1 | 8.00 |
| CHEMBL5568383 | — | — | 1 | 7.99 |
| CHEMBL5287080 | — | — | 1 | 7.91 |
| CHEMBL5564232 | — | — | 1 | 7.88 |
| CHEMBL5565284 | — | — | 1 | 7.86 |
| CHEMBL5555969 | — | — | 1 | 7.80 |
| CHEMBL5559924 | — | — | 1 | 7.77 |
| CHEMBL5567834 | — | — | 1 | 7.67 |
| CHEMBL5566340 | — | — | 1 | 7.57 |
| CHEMBL5562209 | — | — | 1 | 7.55 |
| CHEMBL5560569 | — | — | 1 | 7.50 |
| CHEMBL5560831 | — | — | 1 | 7.45 |
| CHEMBL5565578 | — | — | 1 | 7.40 |
| CHEMBL5561762 | — | — | 1 | 7.40 |
| CHEMBL5557860 | — | — | 1 | 7.30 |
| CHEMBL5560522 | — | — | 1 | 7.20 |
| CHEMBL5559843 | — | — | 1 | 7.20 |
| CHEMBL5568024 | — | — | 1 | - |
| CHEMBL5542986 | — | — | 1 | - |
| CHEMBL5561870 | — | — | 1 | - |
| CHEMBL5542457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561941 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5560595 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5563432 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL5559906 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5558849 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4297639 | LORECIVIVINT | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5559654 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5568383 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5287080 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL5564232 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL5565284 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL5555969 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL5559924 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5567834 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL5566340 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL5562209 | — | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL5560569 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL5560831 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL5565578 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL5561762 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL5557860 | — | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL5560522 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5559843 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5568024 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5542986 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5561870 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5542457 | — | IC50 | > | 100.0 | nM | - |