Assay Detail
Binding
CHEMBL5522375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DYRK1A (unknown origin) incubated for 10 mins in presence of ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.55 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561941 | — | — | 1 | 7.66 |
| CHEMBL4297639 | LORECIVIVINT | 3.0 | 1 | 7.57 |
| CHEMBL5287080 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561941 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL4297639 | LORECIVIVINT | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL5287080 | — | IC50 | = | 37.2 | nM | 7.43 |