Assay Detail
Functional
CHEMBL5522607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of DMBA-stimulated PTX resistance in human A549 cells assessed as PTX IC50 for inhibition of cell viability at 10 uM incubated for 36 hrs in presence of DMBA and PTX by MTT assay (Rvb = 119 +/-2.62 nM)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.77 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5565554 | — | — | 1 | 7.99 |
| CHEMBL5568160 | — | — | 1 | 7.95 |
| CHEMBL5561280 | — | — | 1 | 7.77 |
| CHEMBL5560596 | — | — | 1 | 7.66 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5565554 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5568160 | — | IC50 | = | 11.13 | nM | 7.95 |
| CHEMBL5561280 | — | IC50 | = | 17.11 | nM | 7.77 |
| CHEMBL5560596 | — | IC50 | = | 22.06 | nM | 7.66 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 32.83 | nM | 7.48 |