Assay Detail
Functional
CHEMBL5523024
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Anti-inflammatory activity in mouse macrophages extracted from abdominal activity assessed as inhibition of LPS-induced nitric oxide production at 1 uM measured after 22 hrs by Griess reagent assay relative to control
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.32 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5567931 | — | — | 1 | 4.78 |
| CHEMBL5542810 | — | — | 1 | 4.76 |
| CHEMBL5542106 | — | — | 1 | 4.34 |
| CHEMBL5564890 | — | — | 1 | 4.23 |
| CHEMBL3187788 | — | — | 1 | 4.23 |
| CHEMBL5523606 | — | — | 1 | 4.19 |
| CHEMBL5542501 | — | — | 1 | 4.12 |
| CHEMBL5562073 | — | — | 1 | 4.11 |
| CHEMBL5556543 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5567931 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL5542810 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL5542106 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL5564890 | — | IC50 | = | 59400.0 | nM | 4.23 |
| CHEMBL3187788 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL5523606 | — | IC50 | = | 64100.0 | nM | 4.19 |
| CHEMBL5542501 | — | IC50 | = | 76800.0 | nM | 4.12 |
| CHEMBL5562073 | — | IC50 | = | 78100.0 | nM | 4.11 |
| CHEMBL5556543 | — | IC50 | = | 80300.0 | nM | 4.09 |