Assay Detail
Functional
CHEMBL5523081
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Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.30 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5532369 | — | — | 1 | 5.75 |
| CHEMBL5560751 | — | — | 1 | 5.72 |
| CHEMBL5560746 | — | — | 1 | 5.62 |
| CHEMBL5557736 | — | — | 1 | 5.58 |
| CHEMBL5561551 | — | — | 1 | 5.58 |
| CHEMBL5557794 | — | — | 1 | 5.58 |
| CHEMBL5567858 | — | — | 1 | 5.44 |
| CHEMBL5561277 | — | — | 1 | 5.40 |
| CHEMBL5560868 | — | — | 1 | 5.36 |
| CHEMBL5563273 | — | — | 1 | 5.33 |
| CHEMBL5556268 | — | — | 1 | 5.29 |
| CHEMBL5537096 | — | — | 1 | 5.09 |
| CHEMBL5561635 | — | — | 1 | 5.01 |
| CHEMBL5559255 | — | — | 1 | 4.94 |
| CHEMBL5559028 | — | — | 1 | 4.60 |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | 4.53 |
| CHEMBL4211649 | TINODASERTIB | 2.0 | 1 | - |
| CHEMBL5562512 | — | — | 1 | - |
| CHEMBL5561300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5532369 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5560751 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5560746 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5557736 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5561551 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5557794 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5567858 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5561277 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5560868 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5563273 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5556268 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5537096 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5561635 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5559255 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5559028 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4073443 | TOMIVOSERTIB | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL4211649 | TINODASERTIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL5562512 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5561300 | — | IC50 | > | 50000.0 | nM | - |