Assay Detail
Toxicity
CHEMBL5523086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG expressed in HEK293 cells at -80 mV holding potential by patch clamp analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.70 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.35 |
| CHEMBL5557794 | — | — | 1 | 5.99 |
| CHEMBL5561277 | — | — | 1 | 5.53 |
| CHEMBL5556268 | — | — | 1 | 5.36 |
| CHEMBL5560868 | — | — | 1 | 5.33 |
| CHEMBL5560746 | — | — | 1 | 5.24 |
| CHEMBL5561551 | — | — | 1 | 5.10 |
| CHEMBL5559255 | — | — | 1 | - |
| CHEMBL5559028 | — | — | 1 | - |
| CHEMBL5557736 | — | — | 1 | - |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17157 | TERFENADINE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5557794 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5561277 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5556268 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5560868 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL5560746 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL5561551 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL5559255 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5559028 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5557736 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4073443 | TOMIVOSERTIB | IC50 | > | 30000.0 | nM | - |