Assay Detail
Functional
CHEMBL5524235
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Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMK-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.49 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5565656 | — | — | 1 | 4.60 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5565656 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 42800.0 | nM | 4.37 |