Assay Detail
Binding
CHEMBL5524262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human KDM6B (D1141 to E1590 residues) expressed in Escherichia coli expressing system using histone H3 peptide and L-ascorbic acid as substrate preincubated for 15 mins followed by substrate and 2-OG addition measured after 60 mins by Alphascreen assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pIC50 | 2 | - | - |
| IC50 | 1 | 4.58 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557372 | — | — | 1 | 4.58 |
| CHEMBL1230640 | — | — | 1 | - |
| CHEMBL5542589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557372 | — | IC50 | = | 26302.68 | nM | 4.58 |
| CHEMBL1230640 | — | pIC50 | - | — | - | |
| CHEMBL5542589 | — | pIC50 | - | — | - |