Assay Detail
Binding
CHEMBL5524264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PHD2 (P181 to F426 residues) expressed in Escherichia coli BL21 (DE3) using HIF-1alpha-NODD/CODD as substrate preincubated for 15 mins followed by substrate and 2-OG addition measured after 15 mins by SPE-MS analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pIC50 | 2 | - | - |
| IC50 | 1 | 4.51 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557372 | — | — | 1 | 4.51 |
| CHEMBL1230640 | — | — | 1 | - |
| CHEMBL5542589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557372 | — | IC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL1230640 | — | pIC50 | - | — | - | |
| CHEMBL5542589 | — | pIC50 | - | — | - |