Assay Detail
Functional
CHEMBL5524326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-necroptic activity against human HT-29 cells assessed as cell viability pretreated with compound followed by TNF-alpha/Smac mimetic/Z-VAD-FMK stimulation for 16 hrs by Cell Titer Glo assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel biaryl benzoxazepinones as dual-mode receptor-interacting protein kinase-1 (RIPK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 8.01 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561756 | — | — | 1 | 8.77 |
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 8.54 |
| CHEMBL5561876 | — | — | 1 | 8.52 |
| CHEMBL5560332 | — | — | 1 | 8.52 |
| CHEMBL5565428 | — | — | 1 | 8.48 |
| CHEMBL5556433 | — | — | 1 | 8.47 |
| CHEMBL5568058 | — | — | 1 | 8.46 |
| CHEMBL5567676 | — | — | 1 | 8.42 |
| CHEMBL5562023 | — | — | 1 | 8.24 |
| CHEMBL5561036 | — | — | 1 | 8.12 |
| CHEMBL5562395 | — | — | 1 | 8.08 |
| CHEMBL5566734 | — | — | 1 | 8.08 |
| CHEMBL5568607 | — | — | 1 | 8.06 |
| CHEMBL5556292 | — | — | 1 | 8.01 |
| CHEMBL5558452 | — | — | 1 | 8.00 |
| CHEMBL5563484 | — | — | 1 | 7.96 |
| CHEMBL5568551 | — | — | 1 | 7.93 |
| CHEMBL5561523 | — | — | 1 | 7.90 |
| CHEMBL5568348 | — | — | 1 | 7.85 |
| CHEMBL5563478 | — | — | 1 | 7.69 |
| CHEMBL5564150 | — | — | 1 | 7.56 |
| CHEMBL5567654 | — | — | 1 | 7.52 |
| CHEMBL5559956 | — | — | 1 | 7.48 |
| CHEMBL5562465 | — | — | 1 | 7.25 |
| CHEMBL5565633 | — | — | 1 | 7.22 |
| CHEMBL5562035 | — | — | 1 | 7.08 |
| CHEMBL5561071 | — | — | 1 | - |
| CHEMBL5568096 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561756 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4071864 | GSK2982772 | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5561876 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5560332 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5565428 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5556433 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5568058 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5567676 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5562023 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5561036 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5562395 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5566734 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5568607 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5556292 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5558452 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5563484 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL5568551 | — | EC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5561523 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5568348 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL5563478 | — | EC50 | = | 20.3 | nM | 7.69 |
| CHEMBL5564150 | — | EC50 | = | 27.3 | nM | 7.56 |
| CHEMBL5567654 | — | EC50 | = | 29.9 | nM | 7.52 |
| CHEMBL5559956 | — | EC50 | = | 32.9 | nM | 7.48 |
| CHEMBL5562465 | — | EC50 | = | 56.8 | nM | 7.25 |
| CHEMBL5565633 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5562035 | — | EC50 | = | 82.7 | nM | 7.08 |
| CHEMBL5561071 | — | EC50 | > | 100.0 | nM | - |
| CHEMBL5568096 | — | EC50 | > | 100.0 | nM | - |