Assay Detail
Binding
CHEMBL5524503
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Inhibition of GST-tagged human SGTB expressed in Escherichia coli BL21 (DE3) using NH2-EDASRMEEVD-COOH peptide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by Alpha Screen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.65 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558181 | — | — | 1 | 5.70 |
| CHEMBL5558644 | — | — | 1 | 5.60 |
| CHEMBL5561795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558181 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5558644 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5561795 | — | IC50 | - | — | - |